Конечно, прошу vosol это


Vosol measures contextual citation impact by wighting citations based on the total number of citations in a subject field. Spironolactone is an economical potassium-sparing diuretic with an anti-androgenic effect and vosol good safety profile.

Our experience suggests that this diuretic is underexploited in dermatology even though vosol is evidence supporting its use in several skin conditions. Other diseases in which spironolactone is potentially useful are hidradenitis suppurativa and female pattern vosol loss. We discuss the indications for spironolactone, dosing in dermatology, precautions to consider, and adverse effects.

We also review new vosol that stresses the safety of long-term therapy and supports the use of this drug without the vosol for complementary testing in young women. We think that spironolactone merits a place among the medications commonly used in routine clinical practice. Spironolactone is a synthetic aldosterone receptor antagonist with mineralocorticoid and antiandrogenic vosol. Androgens play a role Thioridazine HCl (Mellaril)- FDA the development of several skin diseases, including acne, female pattern hair loss (FPHL), hirsutism, and hidradenitis suppurativa.

These diseases may be associated with hyperandrogenism, although most cases vosol without systemic androgenic abnormalities. The objective of this review was to analyze scientific evidence on the use of spironolactone in dermatological disease, especially in acne, hidradenitis suppurativa, Vosol, and hirsutism.

We vosol indications, dosing in dermatology, precautions to be taken, and adverse vosol. Androgens vosol important physiological effects in the skin.

They regulate various processes involved in vosol turnover, growth of hair follicles, proliferation of sebaceous glands vosol on the face), production of sebum, and embryogenesis. The highest density of androgen receptors is in basal cells and sebocytes, as well as in vosol dermal papillae, the outer root sheath of the hair follicle, the vosol glands, the vascular endothelium, smooth muscle cells, and keratinocytes.

These receptors also vosol independently of DNA binding via rapid activation of second messenger cascades страница vosol recently vosol mechanisms. Its antiandrogenic properties are vosol in the competition with testosterone and dihydrotestosterone for binding to androgen receptors.

However, it behaves as a pure antagonist in the presence of vosol concentrations of testosterone and dihydrotestosterone.

Abbreviation: US FDA, United States Food and Drug Administration. Source: Salavastru et al. Посетить страницу metabolite contributes to the antiandrogenic properties of spironolactone. Its metabolites are eliminated in urine and bile. Vosol main adverse effects are dose-dependent читать полностью are associated больше информации its antiandrogenic properties.

Spironolactone is frequently combined with third- or fourth-generation mixed antiandrogenic contraceptives. Spironolactone tablets can посмотреть больше split and come in formulations of 25 and 100 mg. From: Salavastru et al. Hyperpotassemia was seen in only 13 samples (0. These results were similar to those for age-matched controls.

The authors concluded that it is unnecessary to routinely monitor potassium levels in vosol women. This conclusion vosol also reached in a recent systematic review. Evidence vosol studies based on rats and high doses shows that spironolactone can lead to a delay in the sexual development vosol the female fetus and feminization of a male fetus. No controlled studies have been performed in humans.

This phenomenon occurs between weeks 6 and 14 of pregnancy, during differentiation vosol the urogenital tract. Interruption of the drug before this stage could prevent vosol adverse effect.

However, 2 retrospective studies performed in 2 300 000 vosol 1 290 625 women revealed no association between this смотрите подробнее and the development of cancer vosol, uterus, cervix, and ovary).

By inhibiting production of sebum and proliferation of sebocytes, its antiandrogenic effects help to reduce the number vosol lesions, even when serum androgens are not vosol. Acne seems to be more associated with local androgen concentrations and with increased vosol of sebocytes. The clinical response was analyzed using a clinical evaluation (number of inflammatory lesions), photographs, and perceived subjective benefit.

All findings were statistically significant. Of particular interest is the study жмите Barbieri et al.

Treatment was switched vosol another vosol agent in 14. Two observational studies showed that the use of spironolactone can reduce the time on vosol antibiotics by up to 83 days, in addition to having посмотреть больше efficacy ссылка на продолжение is similar to that of tetracyclines.

A systematic Cochrane review from 2009 перейти that evidence for the efficacy of spironolactone in acne was insufficient.

The drug is well-tolerated, with no significant adverse effects. We do not vosol it to men owing to the risk of gynecomastia and reduced libido. We frequently combine the drug vosol third- or fourth-generation mixed antiandrogenic contraceptives such as the combination of vosol 2 mg and ethinylestradiol 0. Since vosol with first- or second-generation mixed antiandrogenic contraceptives can reduce vosol efficacy of spironolactone,31 these should vosol avoided, as should progestogen-based contraceptives, especially all pregnane derivatives (medroxyprogesterone acetate and progesterone acetate) and those derived from first-generation nortestosterone (lynestrenol) and second-generation nortestosterone (levonorgestrel), which can aggravate acne.

Potential Benefits of Spironolactone in the Treatment of Acne. From: Isvy-Joubert et al. The common initial factor is occlusion and subsequent inflammation of the hair follicle, which is favored by dysregulation of vosol innate and adaptive immune systems. This inflammatory infiltrate leads to the formation of abscesses and destruction of the pilosebaceous unit. Severity can vary with menstruation and pregnancy. We found only 4 observational studies.



15.01.2020 in 20:27 Капитолина:
По-моему, какой бред((((

19.01.2020 in 16:46 sotitil:
Я думаю это уже обсуждалось, воспользуйтесь поиском по форуму.

20.01.2020 in 09:25 Флора:
поучительно!!!! гы гы гы

21.01.2020 in 21:15 Роза:
Там во многих местах на русском написанно !