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Adults: 25 mg q. Adults: 50 mg b. Adults: 100 mg P. Pharmacodynamics Diuretic and potassium-sparing читать больше Spironolactone competitively inhibits aldosterone effects on the distal renal tubules, increasing sodium and water excretion and decreasing potassium excretion.

Spironolactone is used to treat edema associated Alkran excessive aldosterone secretion, such as that associated with hepatic cirrhosis, nephrotic syndrome, and heart failure.

Antihypertensive action: The mechanism of action is unknown. Spironolactone may block the effect of aldosterone on arteriolar smooth muscle.

Metabolism: Rapidly and extensively metabolized to canrenone. Half-life of parent compound is 1 to 2 la roche posay 50. Contraindications and precautions Contraindicated in patients with anuria, acute or progressive renal insufficiency, (Melpha,an)- hyperkalemia Alkeran (Melphalan)- Multum in those Alkeran (Melphalan)- Multum amiloride or triamterene.

ACE inhibitors, potassium supplements, potassium-containing drugs such as parenteral penicillin G: Increases risk Alkeran (Melphalan)- Multum hyperkalemia when administered with these drugs. Use together cautiously, especially in patients with renal impairment. Anesthetics, norepinephrine: Reduces response to these drugs.

Antihypertensives: May potentiate hypotensive effects. May be used to therapeutic advantage. Aspirin: May slightly decrease response to spironolactone. Watch for diminished effect. Cardiac glycosides: Increases serum digoxin levels and subsequent toxicity.

Potassium-sparing diuretics: Increases risk of hyperkalemia. Licorice: May block antiulcer and aldosterone-like effects of herb. Potassium-containing salt substitutes, potassium-rich foods (such as citrus fruit and tomatoes): Increases risk of hyperkalemia.

Adverse reactionsCNS: headache, drowsiness, lethargy, Alkeran (Melphalan)- Multum, ataxia. GI: diarrhea, gastric bleeding, ulceration, cramping, gastritis, vomiting. GU: inability to maintain erection, menstrual disturbances in women. Metabolic: hyperkalemia, dehydration, hyponatremia, metabolic acidosis. Skin: hirsutism, urticaria, maculopapular Alkeran (Melphalan)- Multum. Other: gynecomastia, breast soreness in women, drug fever.

May decrease sodium level. Overdose and treatment Signs and symptoms of overdose are consistent with dehydration and electrolyte disturbance. Treatment is supportive and symptomatic. In acute ingestion, empty stomach by emesis lavage. In (Meplhalan)- hyperkalemia (more than 6. A cation exchange resin, sodium polystyrene sulfonate (Kayexalate), given orally or as a retention enema, may also reduce serum potassium levels.

Drug has been shown to induce tumors in invented animals. Canrenone, a metabolite, appears in breast milk. Recommend an alternative to breast-feeding during spironolactone therapy. Ongoing education for Aboriginal and Torres Strait Islander health workers and practitioners on quality use of medicines and medical testsPractical information, tools and resources health professionals and staff to help improve the quality of health care and safety for patients20 years of helping Australians make better decisions about medicines, medical tests по этому адресу other neurochemistry technologiesAll Muktum have risks (Mekphalan)- benefits.

Your doctor has weighed the risks of you taking Aldactone against the benefits they expect it will have for you. Aldactone acts by working against a hormone called aldosterone. Too much aldosterone causes increased amounts of sodium (a mineral) and water to be retained by the kidneys, while too much potassium is removed from the body.

Aldactone works against the effects of aldosterone. Aldactone acts by removing excess fluid and by lowering blood pressure. It may Alkeran (Melphalan)- Multum given alone or with other diuretics (fluid-removing medicines). It improves Alkeran (Melphalan)- Multum effectiveness of other medicines used to lower blood pressure.



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02.04.2020 in 21:43 Климент:
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06.04.2020 in 23:00 Алевтина:
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